快穿之精汁欲液勾人H,鲜嫩多汁(快穿 高H),被C哭着爬又被挺进H快穿,快穿被各种男主强好爽H,快穿共妻被C翻了H,快穿做妓女好爽HNP

Toll樣受體信號(hào)通路ChIP PCR芯片 Toll-Like Receptor Signaling Pathway ChIP PCR Array

科技服務(wù) > PCR芯片實(shí)驗(yàn)服務(wù) > Toll樣受體信號(hào)通路ChIP PCR芯片 Toll-Like Receptor Signaling Pathway ChIP PCR Array

Toll樣受體信號(hào)通路ChIP PCR芯片 Toll-Like Receptor Signaling Pathway ChIP PCR Array

Toll樣受體信號(hào)通路ChIP PCR芯片 Toll-Like Receptor Signaling Pathway ChIP PCR Array
運(yùn)費(fèi) ￥0.00
（庫(kù)存 9999 件）
地區(qū)：上海
簡(jiǎn)介：Toll-Like Receptor Signaling Pathway ChIP PCR Array
提供商：SAB
服務(wù)名稱：Toll-Like Receptor Signaling Pathway ChIP PCR Array
Toll-Like Receptor Signaling Pathway ChIP PCR Array

 
ProductSpeciesTechnologyCat. No.
Toll-Like Receptor Signaling Pathway EpiTect ChIP qPCR ArrayHumanHistone ModificationsGH-018A
Toll-Like Receptor Signaling Pathway EpiTect ChIP qPCR ArrayMouseHistone ModificationsGM-018A


The Human Toll-Like Receptor Signaling Pathway EpiTect ChIP qPCR Array profiles the histone modification status or “histone code” of 84 genes central to TLR-mediated signal transduction and innate immunity. Histone modifications regulate chromatin structure and correlate with the transcriptional activity of associated genes. The TLR family of pattern recognition receptors (PRRs) detects a wide range of bacteria, viruses, fungi and parasites via pathogen-associated molecular patterns (PAMPs). Each receptor binds to specific ligands, initiates a tailored innate immune response to the specific class of pathogen, and activates the adaptive immune response. For example, TLR4 recognizes bacterial lipopolysaccharide (LPS) or endotoxin, the compound which causes septic shock during blood-borne infection. The receptors act alone or as heterodimers, interacting with adaptor proteins to initiate MyD88 or TICAM1 (TRIF)-dependent responses. These responses initiate signaling cascades primarily through NF?B, which activates downstream JNK/p38 signaling or cytokine secretion. Dysregulation of these signaling pathways has severe consequences, and causes many autoimmune diseases and chronic pathological inflammation. This array includes members of the TLR signaling family as well as adaptor and effector proteins. Members of the NF?B, JNK/p38, IRF and JAK/STAT signaling pathways downstream of TLR activation are also included. Monitoring the histone modifications of these genes can help determine the epigenetic mechanisms controlling a model system’s ability to mount innate immune responses. Using chromatin immunoprecipitation and EpiTect ChIP qPCR Arrays, research studies can easily and reliably analyze the histone modification patterns associated with a focused gene panel related to TLR-mediated signal transduction.
The EpiTect ChIP qPCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention, or treatment of a disease.



Toll-Like Receptors: CD180 (LY64), SIGIRR, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10.
Pathogen-Specific Responses:
Bacterial: CCL2 (MCP-1), CD14, CD180 (LY64), FOS, HRAS, IL10, IL12A, IL1B, IL6, IL8, IRAK1, HMGB1, JUN, LTA (TNFB), LY86 (MD-1), LY96, NFKBIA (IKBA/MAD3), PTGS2 (COX2), RELA, RIPK2, TLR2, TLR4, TLR6, TNFRSF1A, TICAM1 (TRIF).
Viral: EIF2AK2 (PRKR), IFNB1, IFNG, IL12A, IL6, IRF3, PRKRA, RELA, TBK1, TLR3, TLR7, TLR8, TNF, TICAM1 (TRIF).
Fungal/Parasitic: CLEC4E, HRAS, IL8, TLR2, TIRAP.
TLR Signaling:
Negative Regulation: SARM1, SIGIRR, TOLLIP. 
TICAM1 (TRIF)-Dependent (MYD88-Independent): IRF3, MAP3K7 (TAK1), MAP3K7IP1 (TAB1), NR2C2, PELI1, TBK1, TICAM2, TLR3, TLR4, TRAF6, TICAM1 (TRIF).
MYD88-Dependent: IRAK1, IRAK2, MAP3K7 (TAK1), MAP3K7IP1 (TAB1), MYD88, NR2C2, TIRAP, TLR1, TLR10, TLR2, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TRAF6. 
Downstream Pathways and Target Genes:
NF?B Pathway: BTK, CASP8, CHUK (IKKa), ECSIT (SITPEC), FADD, IKBKB, IL10, IL1B, IRAK1, IRAK2, IRF3, LY96, MAP3K7, MAP4K4, NFKB1, NFKB2, NFKBIA (IKBA/MAD3), NFKBIB, NFKBIL1, NFRKB, PPARA, REL, RELA, TNF, TNFRSF1A, UBE2N, UBE2V1.
JNK/p38 Pathway: ELK1, FOS, IL1B, JUN, MAP2K3 (MEK3), MAP2K4 (JNKK1), MAP3K7, MAPK8 (JNK1), MAPK8IP3, MAPK9, TNF.
JAK/STAT Pathway: CCL2 (MCP-1), CSF2 (GM-CSF), IFNG, IL12A, IL2, IL6.
Interferon Regulatory Factor (IRF) Pathway: CXCL10 (INP10), IFNA1, IFNB1, IFNG, IRF1, IRF3, TBK1.
Cytokine-Mediated Signaling Pathway: CCL2 (MCP-1), CSF3 (GCSF), IL1A, IL1B, IL6, IRAK1, IRAK2, RELA, SIGIRR, TNF, TNFRSF1A.
Regulation of Adaptive Immunity: CD80, CD86, HSPD1, IFNG, IL10, IL12A, IL1B, IL2, MAP3K7, TRAF6.
Adaptors & TLR Interacting Proteins: BTK, CD14, HMGB1, HRAS, HSPD1, LY86 (MD-1), LY96 (MD-2), MAPK8IP3, MYD88, PELI1, RIPK2, SARM1, TICAM1 (TRIF), TICAM2 (TRAM), TIRAP, TOLLIP.
Effectors: CASP8 (FLICE), EIF2AK2 (PRKR), FADD, IRAK1, IRAK2, MAP3K7 (TAK1), MAP3K7IP1 (TAB1), NR2C2, PPARA, PRKRA, ECSIT (SITPEC), TRAF6, UBE2N, UBE2V1.


姓名
電話號(hào)碼
電子郵箱
公司名稱
地址
留言*
 
驗(yàn)證碼
提交
欢迎光临： 石门县| 攀枝花市| 木里| 水富县| 报价| 南康市| 萨嘎县| 汽车| 梨树县| 武胜县| 临漳县| 光泽县| 五河县| 青州市| 东山县| 宁安市| 静安区| 建平县| 北辰区| 临夏市| 昆明市| 亳州市| 辽中县| 永昌县| 泰兴市| 江川县| 寿阳县| 韶山市| 遂平县| 嘉义县| 林西县| 五大连池市| 马尔康县| 永定县| 衡阳县| 固原市| 海晏县| 宁强县| 康马县| 桃江县| 博野县|