上皮間質(zhì)細(xì)胞轉(zhuǎn)化 ChIP PCR 芯片 Epithelial to Mesenchymal Transition (EMT) ChIP PCR Array

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上皮間質(zhì)細(xì)胞轉(zhuǎn)化 ChIP PCR 芯片 Epithelial to Mesenchymal Transition (EMT) ChIP PCR Array

上皮間質(zhì)細(xì)胞轉(zhuǎn)化 ChIP PCR 芯片Epithelial to Mesenchymal Transition (EMT) ChIP PCR Array

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地區(qū)：	上海
簡(jiǎn)介：	Epithelial to Mesenchymal Transition (EMT) ChIP PCR Array
提供商：	SAB
服務(wù)名稱：	Epithelial to Mesenchymal Transition (EMT) ChIP PCR Array

Human Epithelial to Mesenchymal Transition (EMT) ChIP PCR Array
The Human Epithelial to Mesenchymal Transition (EMT) EpiTect Chip qPCR Array profiles the histone modification status or “histone code” of 84 genes key to Epithelial to Mesenchymal Transition (EMT). Histone modifications define chromatin structure, thus playing a key role in the epigenetic-based regulation of gene expression. EMT and the reciprocal mesenchymal to epithelial transition (MET), both mediated by gene expression changes, are key processes involved in both tumor metastasis and stem cell differentiation and development. During EMT, epithelial cells lose apical/basolateral polarity, break intercellular tight junctions, and degrade basement membrane extracellular matrix components to become migratory mesenchymal cells. As such, the array represents cell surface receptor, extracellular matrix, and cytoskeletal genes mediating cell adhesion, migration, motility, and morphogenesis; genes controlling cell differentiation, development, growth, and proliferation; as well as signal transduction and transcription factor genes that cause EMT and all of its associated processes. The results can help you provide further insights into the role of histone modifications in regulating EMT-dependent tumor metastasis and stem cell differentiation and development. Using chromatin immunoprecipitation and this real-time PCR Array, your research study can easily and reliably analyze the histone modification patterns associated with a focused gene panel involved in EMT. The EpiTect Chip qPCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention, or treatment of a disease.

Genes Up-Regulated During EMT: AHNAK, BMP1, CALD1, CDH2 (N-cadherin), COL1A2, COL3A1, COL5A2, FN1, FOXC2, GNG11, GSC, IGFBP4, ITGA5, ITGAV, MMP2 (Gelatinase A), MMP3, MMP9 (Gelatinase B), MSN, SERPINE1 (PAI-1), SNAI1, SNAI2, SNAI3, SOX10, SPARC, STEAP1, TCF4, TIMP1, TMEFF1, TMEM132A, TWIST1, VCAN, VIM, VPS13A, WNT5A, WNT5B.
Genes Down-Regulated During EMT: CAV2, CDH1 (E-cadherin), DSP, FGFBP1, IL1RN, KRT19, MITF, MST1R, NUDT13, PPPDE2, RGS2, SPP1 (Osteopontin), TFPI2, TSPAN13.
Genes with Known Histone Modifications during EMT:
Increased H3K4me3: AHNAK, AKT1, BMP1, CALD1, CAV2, CDH2 (N-cadherin), CTNNB1, FN1, FZD7, GNG11, GSK3B, IGFBP4, ILK, ITGA5, MAP1B, MITF, MMP2 (Gelatinase A), RGS2, SERPINE1 (PAI-1), SNAI1, SNAI2, SPARC, TCF4, TGFB1, TGFB2, TGFB3, TIMP1, TMEFF1, TSPAN13, VIM, VPS13A, WNT5A.
Decreased H3K27me3: DSP, FGFBP1, GSC, IL1RN.
Differentiation & Development: AKT1, BMP1, BMP2, BMP7, COL3A1, COL5A2, CTNNB1, DSP, ERBB3, F11R, FOXC2, FZD7, GSC, KRT14, MITF, MST1R, NODAL, NOTCH1, PTP4A1, SMAD2, SNAI1, SNAI2, SOX10, TGFB2, TGFB3, TMEFF1, TWIST1, VCAN, WNT11, WNT5A, WNT5B.
Morphogenesis: CTNNB1, FOXC2, PPP3R1, RAC1, SMAD2, SNAI1, SOX10, TGFB1, TGFB2, TGFB3, TWIST1, WNT11, WNT5A.
Cell Growth & Proliferation: AKT1, BMP1, BMP2, BMP7, CAV2, CTNNB1, EGFR, ERBB3, FGFBP1, FOXC2, HIF1A, IGFBP4, ILK, MST1R, NODAL, PDGFRB, TGFB1, TGFB2, TGFB3, TIMP1, VCAN.
Migration & Motility: CALD1, CAV2, EGFR, FN1, ITGB1, MSN, MST1R, NODAL, PDGFRB, RAC1, STAT3, TGFB1, VIM.
Cytoskeleton: CAV2, KRT7, MAP1B, PLEK2, RAC1, VIM.
Extracellular Matrix & Cell Adhesion: BMP1, BMP2, BMP7, CDH1 (E-cadherin), CDH2 (N-cadherin), COL1A2, COL3A1, COL5A2, CTGF, CTNNB1, DSC2, EGFR, ERBB3, F11R, FN1, FOXC2, ILK, ITGA5, ITGAV, ITGB1, MMP2 (Gelatinase A), MMP3, MMP9 (Gelatinase B), PTK2, RAC1, SERPINE1 (PAI-1), SPP1 (Osteopontin), TGFB1, TGFB2, TIMP1, VCAN.
Signaling Pathways:
Estrogen Receptor: CAV2, ESR1 (ERa), KRT19, TGFB3.
G-Protein Coupled Receptor: AKT1, FZD7, GNG11, RAC1, RGS2.
Integrin-Mediated: COL3A1, CTGF, ILK, ITGA5, ITGAV, ITGB1, PTK2.
Notch: FOXC2, NOTCH1.
Receptor Tyrosine Kinase: EGFR, ERBB3, PDGFRB, RGS2, SPARC.
TGFb / BMP: BMP1, BMP2, BMP7, COL3A1, SMAD2, SMAD4, TGFB1, TGFB2, TGFB3.
WNT: CTNNB1, FZD7, GSK3B, WNT11, WNT5A, WNT5B.
Transcription Factors: CTNNB1, ESR1 (ERa), FOXC2, GSC, MITF, NOTCH1, SIP1, SMAD2, SNAI2, SNAI3, SOX10, STAT3, TCF4, TWIST1, ZEB2.

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快穿之精汁欲液勾人H,鲜嫩多汁(快穿 高H),被C哭着爬又被挺进H快穿,快穿被各种男主强好爽H,快穿共妻被C翻了H,快穿做妓女好爽HNP

上皮間質(zhì)細(xì)胞轉(zhuǎn)化 ChIP PCR 芯片 Epithelial to Mesenchymal Transition (EMT) ChIP PCR Array

上皮間質(zhì)細(xì)胞轉(zhuǎn)化 ChIP PCR 芯片 Epithelial to Mesenchymal Transition (EMT) ChIP PCR Array

快穿之精汁欲液勾人H,鲜嫩多汁(快穿高H),被C哭着爬又被挺进H快穿,快穿被各种男主强好爽H,快穿共妻被C翻了H,快穿做妓女好爽HNP