阿爾茲海默癥PCR芯片包含了84個可用于研究老年癡呆癥發(fā)生與發(fā)展的重要基因。芯片中包括與β-淀粉樣蛋白（Aβ）的產(chǎn)生、清除和降解有關(guān)的基因，還包括β-淀粉樣蛋白（Aβ）信號轉(zhuǎn)導(dǎo)途徑中參與神經(jīng)毒性和炎癥反應(yīng)的基因。通過實時定量PCR的方法，研究者即能夠利用該芯片簡單可靠地同時檢測阿爾茲海默癥相關(guān)基因的表達。
| Alzheimer’s Disease PCR Array阿爾茲海默癥PCR芯片 |
Beta-Amyloid Generation, Oligomerization, Clearance, & Degradation: Secretases: ADAM9, APH1A, BACE1, BACE2, CTSB, NCSTN, PSEN1, PSEN2. Other Peptidases: IDE, PLAT (tPA), PLAU (uPA), PLG. Endocytosis: APLP1, APP, LRP1, LRP6, LRP8. Other Genes: A2M, ACHE, APBB1, APBB2, APOE, BCHE, UBQLN1. Cytoskeleton Reorganization: APOE, MAP2, MAPT, PKP4, PRKCI. Synaptic Formation: ACHE, APBA1, APBB1, APBB2, APOE, BDNF, CHAT. Lipid Metabolism: ABCA1, APOA1, APOE, CLU, HSD17B10 (HADH2), INS, LPL, LRP1, LRP8, SNCB. Apoptosis: APLP1, APP, CASP3, CASP4, CLU, EP300, ERN1, IL1A, MAPT, MPO, NAE1, PRKCA, PRKCE , PRKCZ, PSEN1, PSEN2, SNCA. Cell Cycle: APBB1, APBB2, CDK1 (CDC2), CDK5, CDKL1, ERN1, EP300, IL1A, NAE1, PRKCA. Cell Signaling Molecules: WNT Signaling: GSK3A, GSK3B, LRP6. Notch Signaling: ADAM10, APH1A, NCSTN, PSEN1, PSEN2. G-protein Coupled Receptor Signaling: APLP2, GNAO1, GNAZ, GNB1, GNB4, GNB5, GNG11, GNG3, GNG4, GNGT1, GNGT2, NTRK1, NTRK2. Intracellular Signaling: APBA3, APBB2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PRKCI, PRKCQ, PRKCZ, PSEN1, PSEN2. Other Genes: GAP43, GNB2, IDE, IL1A, INSR, NAE1, PLAU (uPA). Transcription: APBB1, APBB2, EP300, ERN1. Oxidative Stress: HSD17B10 (HADH2), MPO, UQCRC1, UQCRC2. Proteases & Inhibitors: ADAM10, APLP2, APP, CAPN1, CTSC, CTSD, CTSG, CTSL1, SERPINA3, UQCRC2. |
